Thermo Fisher Scientific Epstein Barr Virus LMP2A Monoclonal Antibody (15F9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Product Specifications

Species Reactivity

Virus

Published species

Not Applicable

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

15F9

Immunogen

Bacterial TrpE-LMP2A fusion protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_936576

Product Specific Information

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections.

Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV).

Target Information

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.