Thermo Fisher Scientific Epstein Barr Virus LMP2A Monoclonal Antibody (15F9)
Epstein-Barr Virus LMP2A 단백질을 인식하는 Rat monoclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Protein G로 정제된 액상 제품이며, PBS buffer 내 0.09% sodium azide를 포함합니다. EBV 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Published Species | Not Applicable |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15F9 |
| Immunogen | Bacterial TrpE-LMP2A fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_936576 |
Product Specific Information
- Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for staining of paraffin sections.
- Rat anti-Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV).
Target Information
Epstein-Barr virus (EBV) is a human herpesvirus associated with conditions such as Hodgkin’s disease and Burkitt’s lymphoma and is the causative agent of infectious mononucleosis. EBV latently infects B lymphocytes, expressing nuclear antigens and latent proteins LMP1, LMP2A, and LMP2B.
LMP2A forms aggregates in the plasma membranes of B lymphocytes, functioning as a negative regulator of Src and Syk protein tyrosine kinases. It blocks B-cell receptor (BCR) signal transduction in EBV-immortalized B cells and may help maintain latent EBV infection in peripheral blood B cells. EBNA-1 is the only viral protein consistently expressed in all EBV-associated malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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