Thermo Fisher Scientific CD80 Monoclonal Antibody (RM80)
Thermo Fisher Scientific의 CD80 단클론 항체(RM80)는 Mouse CD80(B7-1)을 인식하는 Rat IgG2a 형 항체로, FACS 및 IHC(Frozen)에 적합합니다. 단백질 G로 정제된 액상 비결합형 항체이며, PBS buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Assay-dependent
Flow Cytometry (Flow)
- Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RM80 |
| Immunogen | BCL1 cells expressing CD80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2275860 |
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Rat anti-Mouse CD80 antibody, clone RM80 recognizes mouse CD80 (B7-1), an approximately 60 kDa cell surface glycoprotein which is a member of the CD28/B7 family.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, being able to substitute for each other in this process.
CD80 is rapidly induced on the surface of in vitro activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes by binding to CD28 and CTLA4 ligands on T cells.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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