Thermo Fisher Scientific DGKI Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is >95% (by SDS-PAGE).

Target Information

Diacylglycerol (DAG) acts as an intracellular activator of protein kinase C (PKC) and guanine nucleotide exchange factors, influencing numerous signaling cascades. Diacylglycerol kinases (DGKs) regulate DAG levels by phosphorylating it to phosphatidic acid.
Human DGKs are classified into five types:

• Type I: DGK-α, -β, -γ (contain EF-hand motifs)
• Type II: DGK-δ, -ι (contain PH domains)
• Type III: DGK-ε (no identifiable regulatory domain)
• Type IV: DGK-Ω, -ι (contain C-terminal ankyrin repeats)
• Type V: DGK-θ (contains cysteine-rich domains and a PH domain)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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