Thermo Fisher Scientific DR4 Polyclonal Antibody
DR4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역세포염색(ICC/IF)에 사용 가능. 인간, 마우스, 랫트 반응성. PBS 용액 내 0.02% sodium azide 포함, 2–8°C 보관. DR5와 교차 반응 없음.
- 카탈로그번호
- PA519887
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide near the amino terminus of human DR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151932 |
Product Specific Information
- Suggested positive control: HeLa cell lysate
- DR4 antibody has no cross reaction to DR5
- The PA5-19887 immunogen is located within the first 50 amino acids of DR4
- Predicted molecular weight: ~50 kDa
- In Western blot applications, this antibody detects a band at approximately 55 kDa (post-modification: 1 N-linked glycosylation)
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. Its ligand, TRAIL, belongs to the TNF family. DR4 mediates apoptosis and NF-κB activation in various cells and tissues, similar to other death receptors such as Fas and TNFR1.
Apoptosis is a programmed cell death process essential for normal cellular differentiation and development. It is induced by cytokines of the TNF family (e.g., TNF, Fas ligand) binding to their respective death domain-containing receptors (e.g., TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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