Thermo Fisher Scientific MTA2 Monoclonal Antibody (17A1)
MTA2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow cytometry에 적합. NuRD 복합체 구성 성분 연구에 활용 가능하며, 다양한 인체 조직에서 발현. 고순도 Protein A 정제, 안정적 PBS/glycerol buffer 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17A1 |
| Immunogen | Recombinant protein within Human MTA2 aa 77–286 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848856 |
Product Specific Information
Positive Control: K562, MCF-7, SH-SY5Y, Daudi, human colon carcinoma tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human gastric carcinoma tissue, human small intestine tissue.
Target Information
This gene encodes a protein that is a component of the NuRD (nucleosome remodeling deacetylase) complex found in the nucleus of human cells. It has broad expression across many tissues and is part of a small gene family involved in transcriptional regulation, either directly or indirectly through chromatin remodeling.
It is closely related to another family member associated with metastatic potential in certain carcinomas. Both proteins share similar domains, including DNA-binding domains, a dimerization domain, and a methyltransferase-related domain. One known target of this gene product is p53, where deacetylation correlates with reduced growth inhibition in transformed cells, suggesting a link between these gene family members and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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