Thermo Fisher Scientific CD204 Recombinant Rabbit Monoclonal Antibody (10O8B0)
Thermo Fisher Scientific의 CD204 Recombinant Rabbit Monoclonal Antibody (Clone 10O8B0)은 인간, 마우스, 랫트 반응성을 가지며 WB, IHC, ELISA에 사용 가능. HEK293 세포에서 발현된 재조합 항체로, 고순도 affinity chromatography 정제. CD204 관련 대식세포 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10O8B0 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human MSR1 (P21757) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911925 |
Product Specific Information
Positive test controls include: HepG2, HeLa, NIH/3T3, C6.
Immunogen sequence:
MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors are macrophage-specific trimeric integral membrane glycoproteins involved in various macrophage-associated physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.
- Isoforms type 1 and 2 mediate endocytosis of modified low-density lipoproteins (LDLs).
- Isoform type 3 does not internalize modified LDL due to altered intracellular processing and retention in the endoplasmic reticulum.
- Type 3 can inhibit the function of types 1 and 2, suggesting a regulatory mechanism for scavenger receptor activity.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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