Thermo Fisher Scientific DACH1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_5429372) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DACH1,uniProtId:Q9UI36-1,ncbiNodeId:9606,antigenRange:450-570,antigenLength:758,antigenImageFileName:PA5-93268_DACH1_Q9UI36-1_Rabbit.svg,antigenImageFileNamePDP:PA5-93268_DACH1_Q9UI36-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.96 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806698

Product Specific Information

Immunogen sequence: EGRRPGSHPS SHRSSSVSSS PARTESSSDR IPVHQNGLSM NQMLMGLSPN VLPGPKEGDL AGHDMGHESK RMHIEKDETP LSTPTARDSL DKLSLTGHGQ PLPPGFPSPF LFPDGLSSIE T; Positive Samples: Mouse kidney, Mouse lung, Mouse heart, Rat kidney, Rat heart, Rat heart; Cellular Location: Nucleus

Target Information

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.