Thermo Fisher Scientific FMO1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:100

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 363-532 of human FMO1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FMO1,uniProtId:Q01740-1,ncbiNodeId:9606,antigenRange:363-532,antigenLength:532,antigenImageFileName:PA5-93278_FMO1_Q01740-1_Rabbit.svg,antigenImageFileNamePDP:PA5-93278_FMO1_Q01740-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.13 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806701

Product Specific Information

Immunogen sequence: KPTLAIIGLI KPLGSMIPTG ETQARWAVRV LKGVNKLPPP SVMIEEINAR KENKPSWFGL CYCKALQSDY ITYIDELLTY INAKPNLFSM LLTDPHLALT VFFGPCSPYQ FRLTGPGKWE GARNAIMTQW DRTFKVIKAR VVQESPSPFE SFLKVFSFLA LLVAIFLIFL; Positive Samples: Mouse liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane

Target Information

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.