Thermo Fisher Scientific Phospho-ALK (Tyr1078) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors including:

• Anaplastic large cell lymphoma
• Neuroblastoma
• Non-small cell lung cancer

Chromosomal rearrangement is the most common genetic alteration.
The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin (NPM) gene: the 3' half of ALK (chromosome 2) is fused to the 5' portion of NPM (chromosome 5).
The NPM-ALK fusion gene product is oncogenic.

ALK is a novel receptor protein-tyrosine kinase with a putative transmembrane and extracellular domain. These domains are absent in the transforming NPM-ALK gene product.
ALK shows the greatest sequence similarity to LTK and plays an important role in brain development, affecting specific neurons in the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.