Thermo Fisher Scientific Phospho-Amyloid Precursor Protein (Thr729) Polyclonal Antibody
Phospho-Amyloid Precursor Protein (Thr729) 폴리클로날 항체로, 인간 APP의 Thr729 인산화 부위를 인식합니다. Western blot 및 Immunocytochemistry에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 알츠하이머 연구 및 APP 관련 신경생물학 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Amyloid-beta A4 around the phosphorylation site of Thr729 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817558 |
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1.
APP plays a key role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein existing in several isoforms due to alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta-amyloid, the primary component of senile plaques — a hallmark of Alzheimer’s disease.
Abnormal processing of APP is also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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