Thermo Fisher Scientific Phospho-AP2M1 (Thr156) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Target Information

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family.
The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping during the acidification of endosomes and lysosomes.
AP2M1 has been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use the AP-2 complex to enhance endocytosis of both CD4 and class I MHC.
AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein.
At least two isoforms of AP2M1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.