Thermo Fisher Scientific Phospho-MEK6 (Thr28) Polyclonal Antibody
Phospho-MEK6 (Thr28) 특이적 폴리클로날 항체로, 인산화된 MKK6 단백질을 검출합니다. Western blot 및 면역세포염색에 적합하며, 사람, 생쥐, 랫트 시료에 반응합니다. 고순도 정제 및 안정적 PBS/글리세롤 버퍼로 보관됩니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K6 (Accession P52564), corresponding to amino acid residues around phosphorylated Thr28 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817016 |
Product Specific Information
This antibody detects endogenous levels of MKK6 only when phosphorylated at Thr28.
Target Information
MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, functioning as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), serve as integration points for multiple biochemical signals. MKK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. It plays a key role in p38 MAP kinase–mediated signal transduction, influencing processes such as stress-induced cell cycle arrest, transcription activation, and apoptosis.
Tissue specificity:
- Isoform 2: Expressed only in skeletal muscle
- Isoform 1: Found in skeletal muscle, heart, and to a lesser extent in liver and pancreas
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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