Thermo Fisher Scientific Phospho-PLK1 (Tyr217) Polyclonal Antibody
PLK1 단백질의 Tyr217 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 고순도 정제, 1 mg/mL 농도, PBS/glycerol buffer 보존. 세포 분열 및 암 연구용.
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Thermo Fisher Scientific Phospho-PLK1 (Tyr217) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PLK1 (Accession P53350), corresponding to amino acid residues around phosphorylated Tyr217 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817018 |
Product Specific Information
This antibody detects endogenous levels of PLK1 only when phosphorylated at Tyr217.
Target Information
PLK1 is a serine/threonine kinase involved in cell mitosis and acts as a marker of cell proliferation. It plays a critical role in carcinogenesis. Polo-like kinase proteins bind and phosphorylate proteins that are already phosphorylated on motifs recognized by POLO box domains. PLK1 phosphorylates multiple substrates including BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, TP73, TPT1, and WEE1. It is essential for centrosome function and bipolar spindle assembly through phosphorylation of KIZ, NEDD1, and NINL.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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