Thermo Fisher Scientific LATS2 Polyclonal Antibody
LATS2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 세포 내 LATS2 발현 연구 및 종양 억제 경로 분석에 활용됩니다. 액상 형태로 -20°C 보관이 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 70–145 of human LATS2 (NP_055387.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914005 |
Product Specific Information
Positive test controls include:
- Mouse testis
- Rat lung
- Rat testis
- Rat kidney
Localization: Cytoplasm, Nucleus, Centrosome, Cytoskeleton, Microtubule organizing center, Spindle pole.
Immunogen sequence:
FGPYQKALRE IRYSLLPFAN ESGTSAAAEV NRQMLQELVN AGCDQEMAGR ALKQTGSRSI EAALEYISKM GYLDPR
Target Information
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. It interacts with negative regulators of p53 and functions in a positive feedback loop with p53 in response to cytoskeleton damage, leading to centrosome and mitotic apparatus regulation.
LATS2 is essential for maintaining mitotic fidelity and genomic integrity, playing a key role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves STK3/MST2 and STK4/MST1 kinases activating LATS1/2, which phosphorylate and inactivate YAP1 and WWTR1/TAZ, thereby regulating genes involved in cell proliferation, death, and migration.
It also negatively regulates the G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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