Thermo Fisher Scientific MCU Polyclonal Antibody
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Thermo Fisher Scientific의 MCU Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot, IHC, ICC/IF, ELISA 등에 사용 가능. Rabbit IgG 폴리클로날 항체로 고순도 친화 크로마토그래피 정제. 미토콘드리아 칼슘 유니포터 연구에 적합.
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Thermo Fisher Scientific MCU Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 51–170 of human MCU (NP_6123661) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.07 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914009 |
Product Specific Information
- Positive test controls include: HepG2
- Immunogen sequence:
VHQRIASWQN LGAVYCSTVV PSDDVTVVYQ NGLPVISVRL PSRRERCQFT LKPISDSVGV FLRQLQEEDR GIDRVAIYSP DGVRVAASTG IDLLLLDDFK LVINDLTYHV RPPKRDLLSH
Target Information
Mitochondrial inner membrane calcium uniporter (MCU) mediates calcium uptake into mitochondria and forms the pore-forming, calcium-conducting subunit of the uniporter complex (uniplex). Its activity is regulated by MICU1 and MICU2.
- At low Ca²⁺ levels, MCU is down-regulated by MICU1 and MICU2.
- At higher Ca²⁺ levels, MICU1 increases MCU activity.
Mitochondrial calcium homeostasis plays key roles in cellular physiology, regulating bioenergetics, cytoplasmic calcium signaling, and cell death pathways.
MCU is involved in: - Buffering systolic calcium rises in cardiomyocytes
- Regulating mitochondrial calcium during stress response
- Mediating mitochondrial permeability transition in ischemia-reperfusion injury
- Controlling insulin secretion in pancreatic beta-cells
- Influencing muscle size and synaptic vesicle endocytosis kinetics
- Participating in antigen processing and presentation
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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