
Thermo Fisher Scientific SH2D1A Polyclonal Antibody
SH2D1A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Human, Mouse, Rat 시료에 반응하며 Western blot에 적합. 고순도(>95%) 항체로 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human SH2D1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803573 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells.
The protein contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule, acting as an inhibitor by blocking SHP-2 recruitment.
It can also bind to other surface molecules on activated T, B, and NK cells, modulating signal transduction pathways.
Mutations in this gene cause X-linked lymphoproliferative syndrome type 1 (Duncan disease), a rare immunodeficiency associated with Epstein-Barr virus susceptibility, severe mononucleosis, and malignant lymphoma.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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