Thermo Fisher Scientific CST1 Polyclonal Antibody

Thermo Fisher Scientific CST1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA are extracellular (type 2); and kininogens are type 3 cystatins which are intravascular proteins.
All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes.

Cystatin SA, S, and SN are found primarily in saliva, while cystatin S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, whereas cystatin E/M and F moderate cathepsin inhibition.
Fetuins, part of the cystatin superfamily, influence osteogenesis, bone resorption, insulin and hepatocyte growth factor receptor regulation, and systemic inflammation response.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced thrombocyte aggregation.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.