Thermo Fisher Scientific ADORA1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 27–40 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Pig (100%), Dog, Pan …

Target Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical, and pharmacological analyses of the AR genes and proteins have led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3).
Activation of ARs mediates several receptor subtype-specific physiological processes including cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.

The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR causes pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied for its effects on the cardiovascular system.

A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord, modulating neurotransmitter release. In white adipocytes, A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues expressing A1AR include kidney and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.