Thermo Fisher Scientific P-Glycoprotein Polyclonal Antibody
Rabbit polyclonal antibody targeting human P-Glycoprotein (ABCB1/MDR1). Validated for IHC (Paraffin) at 2.5 µg/mL. Affinity-purified and supplied as liquid in PBS with 0.1% sodium azide. Ideal for studying multidrug resistance and ABC transporter...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from cytoplasmic domain of human ABCB1 / MDR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550700 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Marmoset (100%); Monkey (93%); Mouse, Rat, Hamster, Cat, Dog, Pig (80%).
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily.
ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, which is involved in multidrug resistance.
It functions as an ATP-dependent drug efflux pump with broad substrate specificity, reducing drug accumulation in resistant cells and mediating anticancer drug resistance.
Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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