Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody, DyLight 488
IRE1 alpha 단백질을 인식하는 DyLight 488 결합 토끼 폴리클로날 항체로, 인간, 마우스, 랫트에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 4°C 암소 보관, 연구용 전용입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide within the human IRE1 alpha protein (within residues 700–800) |
| Conjugate | DyLight™ 488 |
| Excitation/Emission Max | 492/519 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 50 mM sodium borate |
| Contains | No preservative |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154083 |
Product Specific Information
- This antibody does not react with non-human primate samples.
- Suggested positive control: Pancreatic islets and insulinoma cells.
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1 alpha), is a human homolog of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activity and plays a critical role in ER-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the endoplasmic reticulum, initiating the unfolded protein response by splicing XBP1 mRNA into a potent transcriptional activator.
It is essential for cell viability under stress conditions that cause unfolded protein accumulation in the ER. Null mutants are viable under normal conditions but not under ER stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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