Thermo Fisher Scientific ATF6 Polyclonal Antibody
ATF6 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며, 인간 및 마우스 반응성을 가짐. 액상 형태로 항원 친화 크로마토그래피로 정제됨. ER 스트레스 관련 연구에 적합.
- 카탈로그번호
- PA520215
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 4 publications |
| Immunohistochemistry (IHC) | 5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human ATF6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156621 |
Product Specific Information
A suggested positive control is MCF7 cell lysate.
PA5-20215 can be used with blocking peptide PEP-0347.
Target Information
ATF6 is a transcription factor activated during endoplasmic reticulum (ER) stress, regulating unfolded protein response (UPR) target genes. It binds DNA on the ER stress response element (ERSE) and ERSE II, requiring NF-Y binding for activity.
ATF6 may also participate in transcriptional activation via serum response factor (SRF). It forms homodimers and heterodimers with ATF6 beta and interacts with NF-YC, GTF2I, YY1, and SRF.
Under ER stress, the cleaved N-terminal domain translocates into the nucleus, where the basic domain acts as a nuclear localization signal. The leucine-zipper domain mediates NF-Y binding and ERSE association.
During UPR, a ~50 kDa cytoplasmic fragment is released by sequential proteolysis via site-1 and site-2 proteases. ATF6 is N-glycosylated, phosphorylated by MAPK14/P38MAPK, and belongs to the bZIP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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