Thermo Fisher Scientific Notch2 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla, Red-chested mustached tamarin, Northern white-cheeked gibbon, Kloss’s gibbon, and Crab-eating macaque

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved protein involved in the Notch signaling pathway. It is a type I transmembrane receptor with an extracellular domain containing multiple EGF-like repeats and an intracellular domain with various domain types.
NOTCH2 functions as a receptor for membrane-bound ligands such as Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.