Thermo Fisher Scientific GCN1L1 Polyclonal Antibody
Thermo Fisher Scientific의 GCN1L1 Polyclonal Antibody는 Human, Mouse, Rat에 반응하는 Rabbit IgG 형의 항체입니다. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 아미노산 결핍 반응 연구에 유용한 연구용 항체입니다.
- 카탈로그번호
- A301843A
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GCN1L1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2621 and 2671 of human general control of amino-acid synthesis 1-like 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
GCN1L1 acts as a positive activator of EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. It forms a complex with EIF2AK4/GCN2 on translating ribosomes and facilitates the delivery of uncharged tRNAs to the EIF2AK4/GCN2 tRNA-binding domain, stimulating kinase activity. This process contributes to repression of global protein synthesis and activation of gene-specific mRNA translation, such as ATF4, through EIF2AK4/GCN2-mediated phosphorylation of eIF2α (EIF2S1) on Ser-52, enabling ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.