Thermo Fisher Scientific HEF1 Polyclonal Antibody
HEF1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot 및 IHC(포르말린 고정 파라핀 절편)에서 검증되었으며, 인간, 마우스, 랫트 시료에 반응합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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- PA5102624
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NEDD9 (Accession Q14511), corresponding to amino acid residues S500–N550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852021 |
Product Specific Information
This antibody detects endogenous levels of total NEDD9.
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation.
The Cas family of docking proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases—two key targets for drug development.
HEF1 overproduction increases expression of genes linked to motility, transformation, and invasiveness, including metalloproteinases, MLCK, p160ROCK, and ErbB1.
It also mediates apoptosis in epithelial-derived cell lines such as MCF7 and HeLa.
Overexpression of BCAR1 (p130Cas), a related protein, has been associated with tamoxifen resistance, underscoring the importance of this family in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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