Thermo Fisher Scientific 4-1BB Ligand Recombinant Rat Monoclonal Antibody (TKS-1)
Thermo Fisher Scientific의 4-1BB Ligand Recombinant Rat Monoclonal Antibody (TKS-1)는 마우스 4-1BBL에 특이적으로 결합하며, Flow Cytometry 및 Inhibition Assay에 사용 가능합니다. HEK293 세포에서 발현된 recombinant monoclonal 항체로, Protein A로 정제되어 높은 순도를 제공합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TKS-1 |
| Immunogen | Murine B-cell lymphoma 2PK-3 cells injected into SD rats |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074540 |
Product Specific Information
- Specificity: This antibody binds to murine 4-1BBL and competes with binding of 4-1BB.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells including inflamed endothelial cells, enhancing extravasation of CD137L-expressing monocytes.
Activated T cells express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but not on Hodgkin or T-cell lymphoma.
It is also found in carcinoma cell lines and is thought to be involved in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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