Thermo Fisher Scientific RLBP1 Monoclonal Antibody (OTI1H5), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cellular retinaldehyde-binding protein (CRALBP) plays a crucial role in regenerating 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin.
After photoisomerization of 11-cis-retinal in rod outer segments, it is converted to all-trans-retinal and then to all-trans-retinol. The retinol diffuses into the retinal pigment epithelium (RPE), where it is reconverted to 11-cis-retinol and oxidized to 11-cis-retinal by CRALBP.
Mutations affecting CRALBP function are associated with visual disorders including Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy. CRALBP is a marker for RPE and Müller glial cells of the retina.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.