Thermo Fisher Scientific RLBP1 Monoclonal Antibody (OTI1H5), TrueMAB
RLBP1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot에 최적화됨. 인간 유래 단백질 항원으로 제작되었으며, 동결건조 형태로 제공. 재구성 후 1 mg/mL 농도로 사용 가능하며, 시각 관련 단백질 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H5 |
| Immunogen | Full-length human recombinant RLBP1 protein produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays a crucial role in regenerating 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin.
After photoisomerization of 11-cis-retinal in rod outer segments, it is converted to all-trans-retinal and then to all-trans-retinol. The retinol diffuses into the retinal pigment epithelium (RPE), where it is reconverted to 11-cis-retinol and oxidized to 11-cis-retinal by CRALBP.
Mutations affecting CRALBP function are associated with visual disorders including Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy. CRALBP is a marker for RPE and Müller glial cells of the retina.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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