Thermo Fisher Scientific HTR7 Polyclonal Antibody
HTR7 Polyclonal Antibody는 인간 5-HT7 수용체를 표적으로 하는 토끼 IgG 항체로, IHC(P) 및 ELISA에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS와 0.1% sodium azide 용액에 보관됩니다. 신경생리학 및 정신질환 관련 연구에 활용됩니다.
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Thermo Fisher Scientific HTR7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10–20 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Horse, Guinea pig, Hamster, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminus of human 5HT7 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550330 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Dog, Hamster, Panda, Horse, Pig, Guinea pig (100%); Opossum (90%); Elephant (85%); Pufferfish, Zebrafish (80%).
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
5-HT7 Receptor is a Serotonin Receptor involved in regulation of circadian rhythm and smooth-muscle relaxation in vasculature and GI tract. It has been implicated in depression, autism, and other neuropsychiatric disorders.
Three isoforms documented:
- Isoform a: 445 aa
- Isoform b: 432 aa
- Isoform d: 479 aa
Expression reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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