Thermo Fisher Scientific APH1 Polyclonal Antibody
APH1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. Human, Mouse, Rat 등에서 검증됨. C-말단 유래 합성 펩타이드 면역원. 0.25 mg/mL 농도의 액상 비접합 항체로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 7 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Published species | Human, Mouse, Rat, Tag, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of human Aph-1a |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533367 |
Target Information
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).
The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B), and PEN2, although other components may exist.
APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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