Thermo Fisher Scientific Menin Recombinant Rabbit Monoclonal Antibody (5M7L9)
Recombinant rabbit monoclonal antibody targeting human Menin (clone 5M7L9). Suitable for WB and ELISA. Reacts with human, mouse, and rat samples. Supplied as liquid, unconjugated, affinity-purified, and stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5M7L9 |
| Immunogen | A synthetic peptide corresponding to amino acids 516–615 of human Menin (UniProt ID: O00255) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911948 |
Product Specific Information
Positive test controls include: HeLa, HCT116, HepG2, NIH/3T3, Mouse lung, Mouse brain, Rat lung, Rat brain.
The target is typically localized in the nucleus.
Immunogen sequence:
VSGPPRKPPG TVAGTARGPE GGSTAQVPAP TASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL SFLKRQRKGL
Target Information
Potassium channels are ubiquitously expressed proteins with roles in both excitable and non-excitable cells. The large conductance, calcium-activated potassium channel (Maxi K+) is unique in that its activation depends on both intracellular calcium levels and membrane depolarization. This dual activation is enabled by its structural composition—a Maxi K+ alpha homotetramer containing voltage sensor and calcium-binding domains. In vascular smooth muscle, a beta-subunit associates in a 1:1 ratio, reducing the calcium concentration needed for channel opening by 5–10 fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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