Thermo Fisher Scientific IL-33R (ST2) Monoclonal Antibody (hIL33Rcap), APC, eBioscience
인간 IL-33R(ST2)을 인식하는 단일클론 항체로, 세포표면 및 세포내 염색에 적합. APC 형광체 결합으로 유세포분석에 최적화. IL-33R Human ProcartaPlex™ 키트의 캡처 항체로도 사용 가능. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific IL-33R (ST2) Monoclonal Antibody (hIL33Rcap), APC, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry
- Tested Dilution: 5 µL (0.125 µg)/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | hIL33Rcap |
| Immunogen | Extracellular domain of human IL-33R protein |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2762445 |
Available Formats
Product Specific Information
This hIL33Rcap monoclonal antibody recognizes human IL-33R (ST2). It binds both membrane-bound (ST2L) and soluble (ST2S) forms and is suitable for surface and intracellular staining.
This clone is also used as a capture antibody in the IL-33R (ST2) Human ProcartaPlex™ Simplex Kit (Product # EPX010-12231-901).
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and tested on LAD2 cells. Recommended use: 5 µL (0.125 µg) per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Target Information
IL-33R (ST2) is a receptor for IL-33, part of the IL-1 receptor family. Its extracellular domain has three Ig-like domains that interact with IL-1RAcP and IL-33.
IL-33 binding activates adaptor proteins (MyD88, IRAK1, IRAK4, TRAF6) and downstream NF-κB and MAPK signaling, leading to cytokine release (IL-5, IL-6, IL-8, IL-13).
Two isoforms exist: ST2L (membrane-bound) and ST2S (soluble). Soluble forms may act as decoys to modulate IL-33 signaling.
IL-33R is expressed mainly in mast cells, basophils, and eosinophils. In mice, expression is seen in ILC2 and Th2 cells.
IL-33R signaling is implicated in allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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