Thermo Fisher Scientific His6-DEP-1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 140-370 of human PTPRJ (NP_0028343) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:His6-DEP-1,uniProtId:Q12913-1,ncbiNodeId:9606,antigenRange:140-370,antigenLength:1337,antigenImageFileName:PA5-87692_His6-DEP-1_Q12913-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87692_His6-DEP-1_Q12913-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.42 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804349

Product Specific Information

Immunogen sequence: KSNDTAASEY KYVVKHKMEN EKTITVVHQP WCNITGLRPA TSYVFSITPG IGNETWGDPR VIKVITEPIP VSDLRVALTG VRKAALSWSN GNGTASCRVL LESIGSHEEL TQDSRLQVNI SGLKPGVQYN INPYLLQSNK TKGDPLGTEG GLDASNTERS RAGSPTAPVH DESLVGPVDP SSGQQSRDTE VLLVGLEPGT RYNATVYSQA ANGTEGQPQA IEFRTNAIQV F; Positive Samples: Raji, SW480, Mouse spleen; Cellular Location: Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, ruffle membrane

Target Information

The protein encoded by His6-DEP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for His6-DEP-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.