Thermo Fisher Scientific His6-DEP-1 Polyclonal Antibody
His6-DEP-1 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합. Human과 Mouse 반응성, Affinity Chromatography로 정제. PBS/glycerol buffer에 보관하며 -20°C에서 안정적. 세포막 관련 신호전달 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 140–370 of human PTPRJ (NP_0028343) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804349 |
Product Specific Information
Immunogen sequence:
KSNDTAASEY KYVVKHKMEN EKTITVVHQP WCNITGLRPA TSYVFSITPG IGNETWGDPR VIKVITEPIP VSDLRVALTG VRKAALSWSN GNGTASCRVL LESIGSHEEL TQDSRLQVNI SGLKPGVQYN INPYLLQSNK TKGDPLGTEG GLDASNTERS RAGSPTAPVH DESLVGPVDP SSGQQSRDTE VLLVGLEPGT RYNATVYSQA ANGTEGQPQA IEFRTNAIQV F
Positive Samples: Raji, SW480, Mouse spleen
Cellular Location: Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, ruffle membrane
Target Information
The protein encoded by His6-DEP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate cellular processes such as cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This receptor-type PTP contains:
- An extracellular region with five fibronectin type III repeats
- A single transmembrane region
- A single intracytoplasmic catalytic domain
It is expressed in all hematopoietic lineages and negatively regulates T cell receptor signaling, possibly by interfering with phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells.
It can also dephosphorylate the PDGF beta receptor and may be involved in UV-induced signal transduction.
Multiple transcript variants encoding different isoforms have been identified for His6-DEP-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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