Thermo Fisher Scientific G6B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 18-142 of human C6orf25 (NP_6121211) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:G6B,uniProtId:O95866-1,ncbiNodeId:9606,antigenRange:18-142,antigenLength:241,antigenImageFileName:PA5-87682_G6B_O95866-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87682_G6B_O95866-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.25 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804343

Product Specific Information

Immunogen sequence: NPGASLDGRP GDRVNLSCGG VSHPIRWVWA PSFPACKGLS KGRRPILWAS SSGTPTVPPL QPFVGRLRSL DSGIRRLELL LSAGDSGTFF CKGRHEDESR TVLHVLGDRT YCKAPGPTHG SVYPQ; Positive Samples: K-562, Jurkat, SW620, Mouse intestine, Mouse pancreas, Rat pancreas; Cellular Location: Cell membrane, Endoplasmic reticulum, Golgi apparatus, Golgi apparatus, Single-pass type I membrane protein

Target Information

G6B is a member of the immunoglobulin (Ig) superfamily with 241 amino acids and is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been reported. RT-PCR, Western blot, and flow cytometric analyses suggest that G6B is usually expressed on platelets and cross linking of G6B inhibits platelet aggregation and activation in a calcium-independent manner by agonists such as ADP and collagen-related peptide. G6B is an inhibitory surface receptor on platelets and may be an antithrombotic drug target. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. It is known to bind to heparin. G6B is usually expressed in a restricted set of hematopoietic cell lines like K562, Molt4 and Jurkat and not detected in the cell lines like U937, Raji, Tk, HeLa, NKL, NK62 and YT.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.