Thermo Fisher Scientific C2 Polyclonal Antibody
Thermo Fisher Scientific의 C2 Polyclonal Antibody는 인간 C2 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 ELISA에 적합합니다. 고순도의 친화 크로마토그래피 정제 제품으로, 안정적인 액상 형태와 높은 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 453–752 of human C2 (NP_0000542) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804353 |
Product Specific Information
- Positive Samples: LO2, 293T, U-87MG
- Immunogen sequence:
LDVSKLTDTI CGVGNMSANA SDQERTPWHV TIKPKSQETC RGALISDQWV LTAAHCFRDG NDHSLWRVNV GDPKSQWGKE FLIEKAVISP GFDVFAKKNQ GILEFYGDDI ALLKLAQKVK MSTHARPICL PCTMEANLAL RRPQGSTCRD HENELLNKQS VPAHFVALNG SKLNINLKMG VEWTSCAEVV SQEKTMFPNL TDVREVVTDQ FLCSGTQEDE SPCKGESGGA VFLERRFRFF QVGLVSWGLY NPCLGSADKN SRKRAPRSKV PPPRDFHINL FRMQPWLRQH LGDVLNFLPL
Target Information
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to be associated with certain autoimmune diseases, and SNPs in this gene have been linked to altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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