Thermo Fisher Scientific C2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: LO2, 293T, U-87MG
• Immunogen sequence:
  LDVSKLTDTI CGVGNMSANA SDQERTPWHV TIKPKSQETC RGALISDQWV LTAAHCFRDG NDHSLWRVNV GDPKSQWGKE FLIEKAVISP GFDVFAKKNQ GILEFYGDDI ALLKLAQKVK MSTHARPICL PCTMEANLAL RRPQGSTCRD HENELLNKQS VPAHFVALNG SKLNINLKMG VEWTSCAEVV SQEKTMFPNL TDVREVVTDQ FLCSGTQEDE SPCKGESGGA VFLERRFRFF QVGLVSWGLY NPCLGSADKN SRKRAPRSKV PPPRDFHINL FRMQPWLRQH LGDVLNFLPL

Target Information

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to be associated with certain autoimmune diseases, and SNPs in this gene have been linked to altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.