Thermo Fisher Scientific Phospho-CaMKII (Thr305,Thr306) Recombinant Rabbit Monoclonal Antibody (9H2L7)
Phospho-CaMKII (Thr305,Thr306) 단백질을 표적하는 Thermo Fisher의 재조합 토끼 모노클로날 항체. WB, IHC, ICC/IF에 사용 가능하며 높은 특이성과 민감도, 로트 간 일관성을 제공. 인간 반응성 확인, 다양한 종에서도 예측 반응성 있음.
- 카탈로그번호
- 702357
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H2L7 |
| Immunogen | Peptide corresponding to Human CMK2A (aa 300–309) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2632984 |
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Dog, Sheep, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase regulating cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling calmodulin-independent activity.
CaMKII is ubiquitously expressed and implicated in regulation of the cell cycle, transcription, dendritic spine and synapse formation, neuronal plasticity, and sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle.
In neurons, it plays a structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments independent of kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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