Thermo Fisher Scientific UGGT1 Polyclonal Antibody
UGGT1 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 실험에 적합. 인간 시료 반응성. Affinity chromatography로 정제된 액상 형태로, -20°C에서 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UGGT1 (Accession Q9NYU2), corresponding to amino acid residues E160–F210. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852396 |
Product Specific Information
Antibody detects endogenous levels of total UGGT1.
Target Information
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides.
UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2 moiety of unfolded glycoproteins in a Ca²⁺ dependent reaction.
UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids exposed in the denatured conformation.
It is postulated that UGGT serves as a sensor distinguishing between folded and denatured proteins in the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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