Thermo Fisher Scientific IL-8 Polyclonal Antibody
Thermo Fisher Scientific의 IL-8 Polyclonal Antibody는 고양이 IL-8 단백질에 특이적인 토끼 폴리클로날 항체입니다. WB, ELISA, IP 등 다양한 응용에 적합하며, Protein A로 정제된 고순도 항체입니다. 연구용으로 안정적이고 재현성 높은 결과를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000–1:50,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein raised in yeast, corresponding to 79 amino acids of mature cat IL-8 protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for cat IL-8 protein. A BLAST analysis was used to suggest cross-reactivity with IL-8 from cat sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-8 from other sources has not been determined.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines, bound by cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor.
Its expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous nomenclature includes NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and other CXC chemokines form a gene cluster mapped to chromosome 4q. It plays a role in angiogenesis, tumor growth, and the pathogenesis of bronchiolitis caused by viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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