Thermo Fisher Scientific alpha 1 Antitrypsin Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal Antibody로 다양한 IHC, ICC, Flow, ELISA에 적합. KLH 결합 합성 펩타이드(aa 101-200)로 면역원 제작. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific alpha 1 Antitrypsin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human alpha 1 Antitrypsin, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin. These enzymes may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, the enzymes can digest pulmonary parenchyma, leading to tissue damage. Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress in newborns. Elevated levels are observed as an acute phase response to tissue necrosis and inflammation, and in conditions such as rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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