Thermo Fisher Scientific ALK Polyclonal Antibody
ALK 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, IHC, ICC, Flow Cytometry, ELISA 등 다양한 응용에 적합함. Protein A로 정제된 고순도 항체로 인간, 마우스, 랫트 반응성. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD246, amino acids 329–360 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development. Mutations, rearrangements, and amplifications in the ALK gene have been associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common genetic alteration involves chromosomal rearrangement forming a fusion gene between ALK and nucleophosmin (NPM). The NPM-ALK fusion product is oncogenic. ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, which are absent in the NPM-ALK product. It shows high sequence similarity to LTK and influences neuronal development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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