Thermo Fisher Scientific CDK5 Monoclonal Antibody (4E4)
CDK5 단백질 검출용 마우스 모노클로날 항체로 인간, 설치류, 비인간 영장류 시료에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합합니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E4 |
| Immunogen | Purified recombinant fragment of human CDK5 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2538525 |
Product Specific Information
MA5-17053 targets CDK5 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.
The immunogen is a purified recombinant fragment of human CDK5 expressed in E. coli.
MA5-17053 detects CDK5 with a predicted molecular weight of approximately 35 kDa.
Target Information
CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. The active form of CDK5, also known as neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein derived proteolytically from a 35 kDa brain and neuron-specific protein, essential for its kinase activity.
CDK5 is a crucial regulator of neuronal migration in the developing central nervous system and phosphorylates diverse substrates, implicating it in cellular processes such as adhesion, motility, synaptic plasticity, and drug addiction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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