Thermo Fisher Scientific CSF3 Monoclonal Antibody (OTI1G6), TrueMAB

Applications

• Western Blot (WB): 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

G-CSF (Granulocyte colony stimulating factor) is a cytokine that stimulates the production and antibacterial function of neutrophils and monocytes.
Human G-CSF is an 18.8 kDa protein with 175 amino acids. It is produced by various cell types including monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells.

G-CSF plays a key role in the proliferation, differentiation, and activation of hematopoietic cells and is expressed by certain carcinoma and leukemia cells.
It is encoded by two distinct DNA sequences, producing both high-activity and low-activity isoforms.
G-CSF is highly conserved among species and functions via interaction with its receptor on hematopoietic progenitors, neutrophilic granulocytes, and some carcinoma cell lines.

Clinically, G-CSF is used for:

• Treatment of neonatal infections and acute myocardial infarction
• Granulocyte transfusion in neutropenia
• Therapy for severe infections, sepsis, and chronic autoimmune neutropenia
• Treatment of acute myeloid leukemia, Sweet’s syndrome, and AIDS

G-CSF is also a marker for certain carcinomas (e.g., bladder cancer) and is linked to Kostmann Syndrome when dysfunctional.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.