Thermo Fisher Scientific CSF3 Monoclonal Antibody (OTI3F12), TrueMAB

Applications

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

G-CSF (Granulocyte Colony Stimulating Factor) is a cytokine that stimulates the production and antibacterial function of neutrophils and monocytes.
Human G-CSF is an 18.8 kDa protein with 175 amino acid residues. It is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells.
G-CSF influences proliferation, differentiation, and activation of hematopoietic cells, and is expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells.
It is encoded by two distinct DNA sequences, producing a full-size high-activity and a shorter low-activity isoform.
G-CSF functions via interaction with its receptor on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinically, G-CSF is used for treatment of neonatal infections, myocardial infarction, neutropenia, severe infections, sepsis, autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS.
It is also a marker protein for carcinomas such as bladder cancer and is linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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