Thermo Fisher Scientific TRAF6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Suggested positive control: human thymus, testis cell lysate, antigen standard for TRAF6 (transient overexpression lysate).

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are important regulators of cell death and cellular response to stress.
TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, activating different signaling cascades depending on the TRAFs involved.
For example, TRAF2 and TRAF3 bind to CD40, a NF receptor superfamily member involved in B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2, along with TRAF6, is required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.