Thermo Fisher Scientific TRAF6 Polyclonal Antibody
TRAF6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Flow cytometry에 사용 가능. Human 시료에 반응하며, Protein G로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 3–5 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 410–460 of human TRAF6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2241110 |
Product Specific Information
Suggested positive control: human thymus, testis cell lysate, antigen standard for TRAF6 (transient overexpression lysate).
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are important regulators of cell death and cellular response to stress.
TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, activating different signaling cascades depending on the TRAFs involved.
For example, TRAF2 and TRAF3 bind to CD40, a NF receptor superfamily member involved in B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2, along with TRAF6, is required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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