Thermo Fisher Scientific DFNA5 Polyclonal Antibody
Human DFNA5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), Flow Cytometry에 사용 가능. 1 mg/mL 농도의 액상 형태이며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol, 0.2% BSA)로 보존되며 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human DFNA5/GSDME aa 1–220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854744 |
Product Specific Information
Positive Control:
SiHa cell lysates, rat testis tissue, human thyroid gland tissue, human breast tissue, mouse small intestine tissue.
Target Information
DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue, placenta, brain, heart, liver, lung, and pancreas as two alternatively spliced isoforms (short and long).
Defects in the DFNA5 gene cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss resulting from damage to sound-receiving structures in the brain.
The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes and represents nearly 5% of the human genome. Mutations in genes on chromosome 7 are associated with disorders such as Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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