Thermo Fisher Scientific Caspase 12 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.

This affinity purified antibody is directed against mouse Caspase 12.
A BLAST analysis was used to suggest reactivity with the antigen based on 100% homology with the immunizing sequence.

Target Information

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving caspase-8 and caspase-9 respectively.
The endoplasmic reticulum (ER) stress pathway is the third apoptotic mechanism, and caspase-12 is a key component. Caspase-12 is localized to the ER and activated by ER stress, including disruption of calcium homeostasis, mediating ER stress-induced apoptosis.
It co-localizes with proteins involved in Alzheimer’s disease such as gamma-secretase presenilin and beta-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.