Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Mouse 및 Rat에서 Caspase 12 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA에 적합. Affinity chromatography로 정제된 Liquid 형태로 제공되며, -20°C에서 보관. ER stress 관련 세포 사멸 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 15 µg/mL |
| ELISA | 1:10,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal portion of mouse Caspase 12 conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
This affinity purified antibody is directed against mouse Caspase 12.
A BLAST analysis was used to suggest reactivity with the antigen based on 100% homology with the immunizing sequence.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving caspase-8 and caspase-9 respectively.
The endoplasmic reticulum (ER) stress pathway is the third apoptotic mechanism, and caspase-12 is a key component. Caspase-12 is localized to the ER and activated by ER stress, including disruption of calcium homeostasis, mediating ER stress-induced apoptosis.
It co-localizes with proteins involved in Alzheimer’s disease such as gamma-secretase presenilin and beta-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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