Thermo Fisher Scientific Tnfaip6 Polyclonal Antibody
TNFAIP6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 고순도 Affinity Chromatography로 정제된 액상 제품입니다. -20°C 보관, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA592962
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Positive Sample: Mouse brain
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 18–277 of human TNFAIP6 (NP_0090462) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.32 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806561 |
Product Specific Information
Positive Samples: Mouse brain
Immunogen sequence:
WGFKDGIFHN SIWLERAAGV YHREARSGKY KLTYAEAKAV CEFEGGHLAT YKQLEAARKI GFHVCAAGWM AKGRVGYPIV KPGPNCGFGK TGIIDYGIRL NRSERWDAYC YNPHAKECGG VFTDPKQIFK SPGFPNEYED NQICYWHIRL KYGQRIHLSF LDFDLEDDPG CLADYVEIYD SYDDVHGFVG RYCGDELPDD IISTGNVMTL KFLSDASVTA GGFQIKYVAM DPVSKSSQGK NTSTTSTGNK NFLAGRFSHL
Target Information
The TSG6 gene is expressed in normal fibroblasts and activated by cytokines TNF-α and IL-1 at AP-1 and NF-IL6 promoter sites.
TSG-6 is a glycoprotein belonging to the hyaluronan-binding protein family, including cartilage link protein, proteoglycan core protein, and CD44.
It is highly homologous to CD44, especially in the hyaluronic acid-binding domain.
TSG-6 expression is induced by TNF-α, IL-1, and lipopolysaccharide in fibroblasts, PBMCs, synovial cells, and chondrocytes.
Presence in synovial fluid suggests a role in rheumatoid arthritis.
TSG-6 forms a stable complex with the serine protease inhibitor inter-alpha-inhibitor (IαI), enhancing its inhibitory effect on plasmin activity.
Together, TSG-6 and IαI modulate protease networks and inhibit inflammation.
⚠ WARNING: This product contains mercury, a chemical known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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