Thermo Fisher Scientific Claudin 4 Polyclonal Antibody
Claudin-4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간, 마우스, 염소 등 다양한 종에 반응하며, 액상 형태로 제공됩니다. -20°C 이하에서 보관하며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 6 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Goat, Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the C-terminus of human Claudin-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2082869 |
Product Specific Information
This antibody is predicted to react with bovine, canine, amphibian, mouse, porcine, and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer (pH 6.0) for 10 minutes, followed by cooling at room temperature for 20 minutes.
After antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature.
A suggested positive control is tonsil or ovarian carcinoma.
Target Information
Claudin-4 belongs to the 20-member claudin family, which consists of transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions.
Claudins exhibit tissue-specific expression patterns and are essential for tight junction charge-specific channels regulating paracellular ion flux.
Claudin-4 contributes to tight junction strands and may play a role in internal organ development and function during pre- and postnatal life.
Overexpression of Claudin-4 decreases paracellular electrical conductance due to reduced Na⁺ permeability, without affecting Cl⁻ permeability.
In ovarian carcinoma cells, Claudin-3 and Claudin-4 are upregulated at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and other epithelial cancers.
The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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