Thermo Fisher Scientific SHP-1 Recombinant Rabbit Monoclonal Antibody (3H20L13)
SHP-1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 면역세포염색에 적합합니다. 높은 특이성과 재현성을 제공하며, 동물 유래 성분이 없는 제형으로 제조되었습니다. 인간 반응성, 단기 4°C 보관, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3H20L13 |
| Immunogen | Protein corresponding to human SHP-1 [aa243–aa541] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809241 |
Product Specific Information
This antibody is predicted to react with Monkey, Horse, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase primarily expressed in hematopoietic cells. It consists of two SH2 domains, a catalytic domain, and a regulatory domain. SHP-1 dephosphorylates target proteins to downregulate tyrosine kinase signaling pathways.
In hematopoietic cells, SHP-1 binds to phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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