Thermo Fisher Scientific CMKLR1 Recombinant Rabbit Monoclonal Antibody (7H10L22)

Thermo Fisher Scientific CMKLR1 Recombinant Rabbit Monoclonal Antibody (7H10L22)

Applications

• Immunocytochemistry (ICC/IF): 1:100 dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and omega-3 fatty acid-derived molecule resolvin E1. Interaction with RARRES2 activates signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to effects including reduced immune response, enhanced adipogenesis, and angiogenesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 also positively regulates adipogenesis and adipocyte metabolism and acts as a co-receptor for several SIV strains and a primary HIV-1 strain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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