Thermo Fisher Scientific CMKLR1 Recombinant Rabbit Monoclonal Antibody (7H10L22)
CMKLR1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. 인간에 반응하며 ICC/IF에 적합합니다. 높은 특이성과 일관된 로트 간 품질을 제공하며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific CMKLR1 Recombinant Rabbit Monoclonal Antibody (7H10L22)
Applications
- Immunocytochemistry (ICC/IF): 1:100 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7H10L22 |
| Immunogen | Peptides corresponding to human CMKLR1 (aa11–aa24, aa360–aa373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784587 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and omega-3 fatty acid-derived molecule resolvin E1. Interaction with RARRES2 activates signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to effects including reduced immune response, enhanced adipogenesis, and angiogenesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 also positively regulates adipogenesis and adipocyte metabolism and acts as a co-receptor for several SIV strains and a primary HIV-1 strain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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