Thermo Fisher Scientific Phospho-MEK1/MEK2 (Ser221) Monoclonal Antibody (K.742.1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50

-

Flow Cytometry (Flow)

1:100

-

Product Specifications

Species Reactivity

Dog, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

K.742.1

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pSer221 of human MEK1/2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEK1/2,uniProtId:Q02750-1,ncbiNodeId:9606,antigenRange:221,antigenLength:393,antigenImageFileName:MA5-15118_MEK12_Q02750-1_Rabbit.svg,antigenImageFileNamePDP:MA5-15118_MEK12_Q02750-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:MEK1/2,uniProtId:P36507-1,ncbiNodeId:9606,antigenRange:221,antigenLength:400,antigenImageFileName:MA5-15118_MEK12_P36507-1_Rabbit.svg,antigenImageFileNamePDP:MA5-15118_MEK12_P36507-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

246 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10985371

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.