Thermo Fisher Scientific Stat1 Polyclonal Antibody
Thermo Fisher Scientific의 Stat1 Polyclonal Antibody는 Mouse 및 Rat의 Stat1 단백질을 검출하기 위한 고품질 항체입니다. Western blot과 ELISA에 적합하며, 높은 특이성과 안정성을 제공합니다. Affinity chromatography로 정제된 액상 형태로 -20°C에서 보관 가능합니다.
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Thermo Fisher Scientific Stat1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:25,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Stat1 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for mouse Stat1 protein. BLAST analysis suggests cross-reactivity with Stat1 from mouse and rat based on 100% homology with the immunizing sequence. Partial reactivity is expected against human Stat1 (90% homology). Cross-reactivity with Stat1 from other sources has not been determined.
Target Information
STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism.
STAT1 plays a key role in mediating cell viability in response to various stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2 and is activated through phosphorylation by JAK tyrosine kinases, subsequently translocating to the nucleus to regulate gene transcription.
Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have wide activation profiles. STAT1 responds to ligands such as IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1).
Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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